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Image Search Results
Journal: Pharmaceutics
Article Title: Impact of V9302, a Competitive Antagonist of Transmembrane Glutamine Flux on Reversal of Resistance in Breast Cancer Cell Lines
doi: 10.3390/pharmaceutics16070877
Figure Lengend Snippet: ( A ): Rhodamine 123 accumulation in Pgp-overexpressing mouse T-lymphoma cells in the presence of V9302 at 2, 10, and 20 µM ( A ). Tariquidar was used at 0.2 µM as a positive control. PAR cells represent 100% rhodamine 123 accumulation. ( B ): Pgp ATPase inhibition: V9302 was applied at 20 µM. ∆RLU TC > ∆RLU basal : the tested compound (TC) is stimulator of Pgp ATPase activity; ∆RLU TC = ∆RLUbasal: the tested compound has no effect on Pgp ATPase activity; ∆RLU TC < ∆RLU basal : the tested compound is an inhibitor of Pgp ATPase activity, black line represents the basal Pgp ATPase activity, **** indicates p < 0.0001.
Article Snippet: The
Techniques: Positive Control, Inhibition, Activity Assay